M16. PROFILING GLUTAMATE AND D-SERINE PATHWAYS IN TREATMENT RESISTANT EARLY PSYCHOSIS PATIENTS

Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission.

Although D amino acids are prominent in bacteria, they generally are thought not to occur in mammals. Recently, high levels of D-serine have been found in mammalian brain where it activates glutamate/N-methyl-D-aspartate receptors by interacting with the "glycine site" of the receptor. Because amino acid racemases are thought to be restricted to bacteria and insects, the origin of D-serine in m...

Metacognitive Therapy in Treatment-Resistant Psychosis

Background: More effective psychological treatments for psychosis are required. Case series data and pilot trials suggest metacognitive therapy (MCT) is a promising treatment for anxiety and depression. Other research has found negative metacognitive beliefs and thought-control strategies may be involved in the development and maintenance of hallucinations and delusions. The potential of MCT in...

Metacognitive Therapy in Treatment-Resistant Psychosis

Ionotropic glutamate-like receptor 2 binds D-serine and glycine

*Biostructural Research Unit, Department of Medicinal Chemistry, and §Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark; †Department of Molecular Neurobiology, Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark; and ‡Department of Pharmacology, Emory University School of Medicine, 1510 ...

modern surgical techniques in treatment of patients with cleft lip & cleft palate

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